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Symbol Name ID |
Apc
APC, WNT signaling pathway regulator MGI:88039 |
| Darker colors indicate more annotations |
| Human Phenotypes | Diabetes mellitus |
Exocrine pancreatic insufficiency |
Pancreatic adenocarcinoma |
Small intestine carcinoid |
Adrenocortical adenoma |
Adrenocortical carcinoma |
Papillary thyroid carcinoma |
| Disease(s) Associated with APC | |||||||
| familial adenomatous polyposis 1 | |||||||
| pancreatic cancer |
| Mouse Phenotypes | abnormal large intestine crypts of Lieberkuhn morphology |
abnormal small intestine crypts of Lieberkuhn morphology |
salivary gland epithelial hyperplasia |
adrenal gland hyperplasia |
decreased pancreatic beta cell mass |
decreased pancreatic islet number |
abnormal thymus morphology |
abnormal Hassall's corpuscle morphology |
small thymus |
thymus hypoplasia |
decreased thymocyte number |
abnormal mammary gland development |
absent nipple |
increased mammary gland tumor incidence |
increased mammary adenocarcinoma incidence |
mammary gland hyperplasia |
absent male preputial gland |
prostate gland epithelial hyperplasia |
Harderian gland hyperplasia |
abnormal pancreas development |
absent corpus luteum |
abnormal ovarian follicle morphology |
absent mature ovarian follicles |
abnormal ovarian folliculogenesis |
ovary atrophy |
ovary cyst |
increased ovary tumor incidence |
increased granulosa cell tumor incidence |
increased prostate gland adenocarcinoma incidence |
increased prostate intraepithelial neoplasia incidence |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Apctm1Rfo/Apctm1Rfo | |||||||||||||||||||||||||||||||
| ApcM1Tno/Apc+ | |||||||||||||||||||||||||||||||
| ApcMin/Apc+ | |||||||||||||||||||||||||||||||
| Apctm1Cip/Apc+ | |||||||||||||||||||||||||||||||
| Apctm2Rfo/Apc+ | |||||||||||||||||||||||||||||||
| Apctm1Kk/Apctm1Kk Tg(Lck-cre)1Cwi/? (conditional) |
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| Apctm1Rsmi/Apctm1Rsmi Pgrtm2(cre)Lyd/Pgr+ (conditional) |
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| Apctm1Tno/Apctm1Tno Tg(Pbsn-cre)4Prb/0 (conditional) |
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| Apctm2.1Cip/Apctm2.1Cip Tg(Vil1-cre/ERT2)23Syr/0 (conditional) |
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| Apctm2Rak/Apctm2Rak Tg(KRT14-cre)8Brn/0 (conditional) |
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| Apctm2Rak/Apctm2Rak Tg(Pdx1-cre)6Tuv/0 (conditional) |
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| Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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